Comprehensive Hepatology Trials
Specialized Hepatic
Impairment Trials
With extensive expertise and a long-standing history in early-phase clinical trials for patients with hepatic impairment, CRS has established itself as a leading CRO in this specialized field since the early 1990s. Over the years, we have successfully completed over 100 trials, affirming our status as a trusted leader in hepatology research.
More recently, CRS has expanded its focus to include trials involving patients with hepatic insufficiency, nonalcoholic steatohepatitis (NASH), and liver cirrhosis. Our team is adept at handling complex pharmacokinetic (PK) and pharmacodynamic (PD) designs, dose titrations, various drug formulations, and multiple routes of administration, managing both blinded and unblinded studies with precision. Annually, we manage approximately three to five hepatic impairment clinical trials, each spanning four to six months.
Our team at the CRS Kiel Unit is the cornerstone of our success in hepatic impairment trials. Their extensive experience allows us to develop targeted strategies and customized design solutions, ensuring the rapid and successful development of our clients’ products.
Patient Recruitment and Accredited Lab Support
With direct access to a network of leading hepatologists, hepatology outpatient clinics, and specialists at the University Hospital of Kiel, we ensure the highest level of expertise and reliability. This network, along with our comprehensive database, facilitates easy identification and rapid recruitment of suitable patients, including matched elderly controls, ensuring a quick start and timely completion of our trials.
Our local medical lab partner, LKF, specializes in supporting clinical trials and provides reliable, rapid turnaround of laboratory results, often within six hours. This capability supports efficient screening, review of inclusion/exclusion criteria, and close safety monitoring of trial participants.
Our Advanced Hepatic Assessment Techniques
- Sonography
- Fibroscan
- Fibrotest
- Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) Imaging (via external facilities)
- Child-Pugh Classification
- MELD-Score (Model of End-Stage Liver Disease Score)
- Number Connection Test
- Specialized Liver Parameters and Tests
- Comprehensive Liver Check-Up Test
Patient-centered Hepatology Research
Join us in our commitment to patient safety and improving health through advancing hepatology research. Our experienced team of scientists, project managers, and medical writers will collaborate with you on study design, protocol development, and the communication of findings that directly impact patient outcomes.
Partner with us to advance solutions for liver health and achieve your clinical trial objectives with our patient-centered approach and expertise.
Reach out today to contribute to significant discoveries that benefit patients worldwide.