Driving Progress in Endometriosis
Research
Understanding
Endometriosis
Endometriosis is a condition where tissue that is similar to the lining of the uterus grows outside the uterus, causing a range of symptoms that are often difficult to treat.
About 10% of women of reproductive age and 70% of women with chronic pelvic pain have endometriosis. The exact cause is still unknown, but it might involve factors like menstrual blood flowing backward, stem cells implanting outside the uterus, embryonic tissue remnants, and changes in blood cells. Genetics, hormone resistance, inflammation, new blood vessel growth, oxidative stress, resistance to cell death, and immune system issues may also play a role.
Women with endometriosis often experience painful periods, pain during or after sex, painful urination, infertility, and fatigue. Getting a diagnosis can take time, leading to unnecessary pain and a lower quality of life. Early detection and new treatments are crucial for improving the lives of those affected by this condition.
The Need for Better Care
Endometriosis is typically suspected based on symptoms and confirmed through imaging techniques. The most reliable way to diagnose it is through laparoscopy, where lesions are visually inspected and analyzed. However, this surgical approach, while diagnostic, may not always be curative and involves risks.
Current treatments focus on symptom management and, for those seeking pregnancy, achieving conception. Hormone therapies and pain relievers are commonly prescribed but have limited effectiveness and potential side effects.
Understanding the complexity of endometriosis is vital for providing personalized care and highlights the urgent need for research into more effective therapies.
Advancing Endometriosis Research
We excel in conducting comprehensive women’s health studies, specializing in areas such as endometriosis, polycystic ovary syndrome (PCOS), contraception, heavy menstrual bleeding, hormone replacement/postmenopausal status, sexual dysfunction, uterine fibroids, and in vitro fertilization. Our methods include:
- Gynecological Examination
- Transvaginal Ultrasound
- Vaginal Cytology
- Endometrial Biopsy
- Insler Score
- Hoogland Score
- Monitoring of Follicular Growth/Ovulation
- Rating Scales/Questionnaires: Assessments for quality of life, sleep quality, and pain levels
Our Commitment
to Improving
Endometriosis Care
At CRS, we are deeply committed to advancing clinical trial recruitment in endometriosis and women’s health. We utilize a comprehensive database of volunteers and patients, supported by a network of respected medical specialists, family doctors, and gynecologists. Our state-of-the-art early phase units ensure adherence to Good Clinical Practice (GCP) standards and regulatory requirements set forth by authorities such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
We collaborate closely with leading clinical centers to conduct studies that range from preclinical investigations to proof-of-concept trials. Our research spans from preclinical investigations to proof-of-concept trials involving both healthy individuals and patients with endometriosis, driven by a deep commitment to improving care. We leverage our extensive experience in navigating clinical trial authorization processes and actively engage in scientific advisory meetings with regulatory bodies to ensure rigorous adherence to strict scientific standards. Our multidisciplinary team of scientists, medical experts, statisticians, and medical writers works tirelessly to translate research findings into meaningful advancements that improve the quality of life for patients with endometriosis.
Join us in pioneering new paths for endometriosis treatment and research. Together, we can create a healthier future for women worldwide.